Development and in-vitro Evaluation of Buccoadhesive Metoclopramide Hydrochloride Tablet Formulations

Buccoadhesive tablets of Metclopramide Hydrochloride were fabricated with objective of avoiding extensive first pass metabolism and to prolong its duration of action with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Chitosan, HPMC K4M and HPMC K15M. Tablets were prepared by direct compression method using polymer in different ratios. The tablets were evaluated for dimension (diameter and thickness), hardness, friability, weight variation, uniformity of content, surface pH study, in-vitro swelling study, matrix erosion study, in-vitro bioadhesion study, ex-vivo mucoadhesion time, in-vitro drug release study and subjected to stability study. Formulation (F4) containing Carbopol 934P and HPMC K4M in the ratio of (1:1) showed good bioadhesive force and maximum drug release of 96.10% in 10 hours. The surface pH of all tablets was found to be satisfactory, close to buccal pH, hence no irritation would observe with these tablets. FTIR studies showed no evidence on interaction between drug and polymers. It was observed that the optimized formulation follows korsmeyer-peppas release kinetics.